Non Steroidal Anti-Inflammatory Drugs (NSAIDs) -2

Adverse reactions:
There are many other potential side effects, but these vary according to the drug chosen and the individual taking it. The other side effects are far less likely to occur.

One of the non steroidal anti-inflammatory drugs:
" Phenylbutazone" is especially likely to cause very serious side effects. These serious side effects are more likely to occur in patients 40 years of age or older than in younger adults, and the risk becomes greater as the patient's age increases. Before you take Phenylbutazone, be sure that you have discussed its use with your doctor. Also, do not use Phenylbutazone to treat any painful condition other than the one for which it was prescribed by your doctor.
Specific allergy to a NSAIDs can be quite dramatic, with rash, swelling of the face, and sometimes difficulty breathing. (If this happens you should call for help urgently.) As with other drugs, if you get a reaction which you suspect to be a side effect, stop taking it and check with your doctor. Sometimes, if the reaction involves an itchy rash and or swelling, it is worth trying an antihistamine in the meantime e.g. Loratin tablets.
Some people with asthma react to the NSAIDs by getting wheezier. If this happens you should stop the drug, and use your usual asthma medication, calling the doctor if this does not work.

More common effects:
  • Abdominal or stomach cramps
  • Pain
  • Discomfort (mild to moderate
  • Dizziness
  • Drowsiness
  • Lightheadedness
  • Headache (mild to moderate
  • Heartburn
  • Indigestion
  • Nausea or vomiting
  • Diarrhea (if taking mefenamic acid, stop taking it and check with your doctor immediately)

Less common or rare effects:
Bitter taste or other taste change; bloated feeling, gas, or constipation; decreased appetite or loss of appetite; fast or pounding heartbeat ; flushing or hot flashes; general feeling of discomfort or illness; increased sensitivity of eyes to light; increased sensitivity of skin to sunlight; increased sweating; irritation, dryness, or soreness of mouth; nervousness, anxiety, irritability, trembling, or twitching; rectal irritation (with suppositories); trouble in sleeping; unexplained weight loss; unusual tiredness or weakness without any other symptoms.
Although not all of the side effects listed above have been reported for all of these medicines, they have been reported for at least one of them. However, since all anti-inflammatory analgesics are very similar, it is possible that any of the above side effects may occur with any of these medicines.
Some side effects may occur many days or weeks after you have stopped using Phenylbutazone.

During this time check with your doctor immediately if you notice any of the following side effects:
Sore throat and fever; ulcers, sores, or white spots in mouth; unusual bleeding or bruising ; unusual tiredness or weakness.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Before Using This Medicine:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your health care professional will make. For the non-steroidal anti-inflammatory drugs.

The following should be considered:
Allergies:
Tell your health care professional if you have ever had any unusual or allergic reaction to any of the non_steroidal anti-inflammatory drugs, or to any of the following medicines:
  • Aspirin or other salicylates
  • Ketorolac
  • Oxyphenbutazone
  • Suprofen
  • Zomepirac
Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet:
Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet. Some of these medicines contain sodium or sugar.

Pregnancy:
Studies on birth defects with these medicines have not been done in humans. However, there is a chance that these medicines may cause unwanted effects on the heart or blood flow of the fetus or newborn baby if they are taken regularly during the last few months of pregnancy. Also, studies in animals have shown that these medicines, if taken late in pregnancy, may increase the length of pregnancy, prolong labor, or cause other problems during delivery. If you are pregnant, do not take any of these medicines, including nonprescription (over-the-counter [OTC]) ibuprofen or naproxen, without first discussing its use with your doctor.

Studies in animals have not shown that:
  • Fenoprofen, Floctafenine, Flurbiprofen, Ibuprofen, Ketoprofen,
    Nabumetone, Phenylbutazone, Piroxicam, Tiaprofenic acid
    , or Tolmetin causes birth defects.
  • Diflunisal caused birth defects of the spine and ribs in rabbits, but not in mice or rats.
  • Diclofenac and Meclofenamate caused unwanted effects on the formation of bones in animals.
  • Oxaprozin caused birth defects in animals.
  • Indomethacin caused slower development of bones and damage to nerves in animals.
  • In some animal studies, Sulindac caused unwanted effects on the development of bones and organs.
  • Studies on birth defects with Mefenamic acid have not been done in animals.

Even though most of these medicines did not cause birth defects in animals, many of them did cause other harmful or toxic effects on the fetus, usually when they were given in such large amounts that the pregnant animals became sick.
For naproxen: Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding:

  • Indomethacin: Indomethacin passes into the breast milk and has been reported to cause unwanted effects in nursing babies.
  • Meclofenamate: Use of meclofenamate by nursing mothers is not recommended, because in animal studies it caused unwanted effects on the newborn's development.
  • Nabumetone: Use of Nabumetone is not recommended because it may cause unwanted effects in nursing babies
  • Naproxen: Use of naproxen is not recommended because it may cause unwanted effects in nursing babies
  • Phenylbutazone: Phenylbutazone passes into the breast milk and may cause unwanted effects, such as blood problems, in nursing babies.
  • Piroxicam: Studies in animals have shown that piroxicam may decrease the amount of milk.
    Although other anti-inflammatory analgesics have not been reported to cause problems in nursing babies, Diclofenac, diflunisal, fenoprofen, flurbiprofen, meclofenamate, mefenamic acid, naproxen, piroxicam, and Tolmetin pass into the breast milk. It is not known whether etodolac, floctafenine, ibuprofen, ketoprofen, Nabumetone, Oxaprozin, sulindac, or tiaprofenic acid passes into human breast milk.

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