Each tablet contains:
Levofloxacin...............................250
& 500mg
Each vial 100ml contains:
Levofloxacin...............................500mg
Properties:
Levofloxacin is
a synthetic broad spectrum antibacterial
fluroquinolone which is levorotatory form of
ofloxacin. Levofloxacin act on DNA gyrase.
An enzyme required for DNA replication,
repair and recombination.
Levofloxacin is bactericidal and has a wide
antibacterial spectrum that covers many Gm
negative and Gm positive and atypical
bacteria and anaerobes.
There is no cross resistance between
Levofloxacin and other groups of
antibacterial agents .
The bioavailability reaches 100%, it
penetrates well to different body tissues.
Levofloxacin has a duration of action of 24
hours and it is eliminated mainly via
kidney.
Indications:
Treatment of bacterial infections
due to Levofloxacin susceptible micro organisms . ►Sinusitis due H.influenza, pneumonia,S.aureus.M.catarrhailis,E.coli,
H.parainfluenzae and k peneumonia. ►Community Acquired pneumonia:due to H.influenza, S.aureus, M.catarrhails,
K.pneumonia, E.coli,Mycoplasma, chlamydia and legionella pneumphila. ►Complicated urinary tract infections and acute pyelonephritis due to :E.coli,
K.pneumoniae, S.faecalis, P.mirabilis,Enterobacter cloacae, p.aerugnosa. ►Uncomplicated skin and skin strructure infections : due to S.pyogenes,
P.mirabilis, P.aeroginosa, E.coli, K.pneumoniae,S.fecalis. ►Complicated skin and skin structure: due to
S.pyogenes,P.mirabilis,E.coli,S.fecalis.E.colacae. ►Intra_abdominal infections: due to E.coli and anaerobic micro organisms.
Contra-indications:
Hypersensitivity to quinolones,epilepsy,
children or adolescents, pregnancy and
lactation.
Precautions:
►Levofloxacin may alter reactivity
such as driving or operate machinery may be impaired. ►Although photo sensation is rare exposure to strong sunlight or U.V is not
recommended. ►False
negative results in diagnosis of T.B due to
inhibition of growth of mycobacterium
tuberculosis by Levofloxacin.
Drug interactions:
Levofloxacin should not be used in
association with iron salts, antacids,
sucralfate and theophylline.
Dosage and administration:
Orally...................500 mg daily (one
tablet 500 mg once or one tablet 250 mg
twice daily).
I.V. Infusion......... (500mg / daily).
I.V. solution for infusion should be infused
slowly over a period of not less than 60
minutes for a dosage of 500 mg.
N.B:
I.V infusion compatible with:
0.9% Sodium chloride solution.
5%dextrose.
2.5%dextrose in Ringer solution.
In patients with renal function impairment
(creatinine clearance <50ml/min) half the
dose is given.
Adverse reactions:
►Venaxan is well tolerated.
the most common adverse reactions are nausea, abdominal discomfort,
headache & dizziness. ►skin rashes & photosensitivity reaction can also occur.
Storage:
Keep at temp. not exceeding 30°C
Keep out of reach of children.
