►In
cases of Pulmonary Embolism and Deep Venous
Thrombosis:
|
Priming infusion dose |
4400 IU/ Kg at a rate of 90 ml /hr
|
|
Followed by |
|
Continuous infusion
dose
|
4400 IU Kg at a rate of 15 ml / hr over a period
of 12 hrs |
►►Coronary
artery Thrombosis and Myocardial Infarction:
►Intracoronary
Route:
Before the administration of urokinase prior
bolus 2500 – 10,000 Units of heparin should
be administered through intravenous
administration.
Reconstitute three vials of Angikinase
250,000 IU by aseptically adding 5 ml of
sterile water for injection.
Then Angikinase is infused at a rate of 4ml
/min into the occluded artery for a period
up to 2 hours.
►Intravenous
route:
Angikinase is also administered at doses of
2 -3million units over 45 – 90 minutes.
►►Peripheral
arterial- thromboembolism :
Urokinase is infused in the clot via a
catheter at a rate of 4000 IU / min and the
catheter is advanced every 2 hours till flow
is resumed .then at a rate of 1000 IU / min
till complete clot lysis occurs.
N.B: Preparation of reconstituted
material
1. it is important to reconstitute only with
sterile water for injection for injection
without preservatives
2. Do not use bacteriostatic water for
injection.
3. To minimize the formation of filaments
avoid shaking the vial during
reconstitution. Only Roll and tilt the vial
during reconstitution.
4. Do not add other medications to the
solution.
5. Because urokinase contains no
preservatives do not reconstitute until
immediately before use.
6. Discard any unused portion of the
reconstituted material.
|
