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Vitamin E- 4

Vitamin E and the risk of Alzheimer's disease:
Some evidence on the role of vitamin E in reducing the risk of Alzheimer's disease was reported in three recent studies:
The first study:
Conducted at the Rush Institute for Healthy Aging of the Rush-Presbyterian-St Luke's Medical Center found that an increased vitamin E intake from foods was associated with a decreased risk of developing Alzheimer's disease.
The second study:
Conducted in the Netherlands, showed that vitamin E from food, but not other antioxidants, may be associated with a decreased risk.
The third study:
Which was conducted in Italy, evaluated a high dose of 2,000 IU and found a substantial protective effect. It appears that the effect of vitamin E from supplements is detectable only with high doses.

Vitamin E and Sperm:
Department of Clinical Biochemistry, College of Medicine, King Saud University, Abha Branch, Saudi Arabia.

Asthenospermia: is the main factor of male infertility among patients consulting the Asir Infertility Center in Abha, Saudi Arabia. Lipid peroxidation occurring in both the seminal plasma and spermatozoa was estimated by malondialdehyde (MDA) concentration. Spermatozoal MDA concentration was higher in men with decreased sperm motility. The MDA concentration in the seminal plasma exhibited no relationship with sperm concentration, sperm motility, the number of immotile spermatozoa, or even the absence of spermatozoa. The MDA concentration in sperm pellet suspensions of asthenospermic and oligoasthenospermic patients was almost twice that of the normospermic males. The MDA concentration in the sperm pellet suspension from normospermic or oligospermic patients was about 10% that in the seminal plasma. However, the MDA concentration in the sperm pellet suspension of asthenospermic or oligoasthenospermic patients was about 15% that in the seminal plasma. Treatment of asthenospermic patients with oral Vitamin E significantly decreased the MDA concentration in spermatozoa and improved sperm motility. Eleven out of the 52 treated patients (21%) impregnated their spouses; nine of the spouses successfully ended with normal term deliveries, whereas the other two aborted in the first trimester. No pregnancies were reported in the spouses of the placebo-treated patients.
In addition, vitamin E has been shown to increase the ability of sperm to fertilize an egg in test tubes.

High-dose vitamin E: has been tested as a treatment for sub fertility in men. Increasing the levels of vitamin E in men with low fertility resulted in improving the number and quality of sperm. The sperm had improved mobility and were better able to attach to the unfertilized egg.By mopping up superoxide free radicals, doses as high as 600 mg vitamin E per day have shown a significant benefit on sperm numbers.
This leaves vitamin E in an inactive form which is rapidly reactivated by vitamin C. It is therefore important for men to obtain adequate dietary supplies of both vitamins. Studies have shown that vitamin E is more effective when taken with another key antioxidant, vitamin C. The reason may be that when a vitamin E molecule is damaged by interacting with a free radical, C converts it back to its original form, giving it, in effect, a second life. To minimize stomach upset, take vitamin E at mealtimes or with a snack.
Vitamin E is a component of the non-specific sperm agglutinin (NSSA) and, together with vitamin C, plays a role in preventing sperm clumping and promoting motility. It also has a beneficial effect on the flexibility of sperm cell walls.

Dosage: In studies, a daily dose of 600 lUs of vitamin E was used. Don't take more than 800 l.U.s a day. Choose a product containing mixed tocopherols. Begin by taking 200 IU daily, then gradually increase the dosage until you are taking 400 IU twice daily.
Supplements containing up to 100 mg of vitamin E are useful for general sperm health. In sub fertility, doses up to 600 mg may be suggested by an andrologist. Vitamin E is non-toxic and seems safe at doses of 1,000 mg per day or more.
Note: If you have high blood pressure, limit your intake of supplemental vitamin E to a total of 400 IU daily.

Studies suggest that Vitamin E may be as effective -and possibly more effective- than expensive high-tech procedures.

What is the health risk of too much vitamin E?
The health risk of too much vitamin E is low; it is considered to be the least toxic of all the fat-soluble vitamins.A recent review of the safety of vitamin E in the elderly concluded that taking vitamin E supplements for up to 4 months at doses of 530 mg or 800 IU (35 times the current RDA) had no negative side-effect on general health, body weight, levels of body proteins, lipid levels, liver or kidney function, thyroid hormones, amount or kinds of blood cells, and bleeding time.
However, levels of vitamin E in excess of 1200 IU daily may interfere with absorption and metabolism of vitamins A and K and then it may interfere with blood clotting and potentiate blood-thinning medications such as dicumarol; hence, a recommended upper limit for daily intake of 1000 milligrams (1500 IU of R,R,R-alpha-tocopherol) has been set.
ODS is working on updating this section of the vitamin E fact sheet to include the results of meta-analyses and clinical trials that have been published recently. A new version will be posted shortly.

The Food and Nutrition Board of the Institute of Medicine has set an upper tolerable intake level (UL) for vitamin E at 1,000 mg (1,500 IU) for any form of supplementary alpha-tocopherol per day. Upper tolerable intake levels "represent the maximum intake of a nutrient that is likely to pose no risk of adverse health effects in almost all individuals in the general population".
 
Caution! People with anemia, poorly clotting blood, liver disease, or overactive thyroid should not take vitamin E supplements without consulting a doctor. If you are taking an anticoagulant (blood thinner), consult your physician before taking supplemental vitamin E.
Vitamin E requires the presence of fats and bile in the gut to be absorbed. The degree to which vitamin E is absorbed by the body is dependent on the total absorption of dietary fat.

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