Composition: Each tablet contains:
Levofloxacin...............................250 and 500mg
Each vial 100ml contains:
a synthetic broad spectrum antibacterial
fluroquinolone which is levorotatory form of
ofloxacin. Levofloxacin act on DNA gyrase.
An enzyme required for DNA replication,
repair and recombination.
Levofloxacin is bactericidal and has a wide
antibacterial spectrum that covers many Gm
negative and Gm positive and atypical
bacteria and anaerobes.
There is no cross resistance between
Levofloxacin and other groups of
antibacterial agents .
The bioavailability reaches 100%, it
penetrates well to different body tissues.
Levofloxacin has a duration of action of 24
hours and it is eliminated mainly via
Indications: Treatment of bacterial infections due to Levofloxacin
susceptible micro organisms. b:Sinusitis due
H.influenza, pneumonia ,S.aureus, M.catarrhailis, E.coli,
H.parainfluenzae and k pneumonia. ► Community
Acquired pneumonia: due to H.influenza,
S.aureus, M.catarrhails, K.pneumonia,
E.coli, Mycoplasma, chlamydia and legionella
pneumphila. ► Complicated
urinary tract infections and acute
pyelonephritis due to :E.coli, K.pneumoniae,
cloacae, p.aerugnosa. ► Uncomplicated
skin and skin structure infections : due to
S.pyogenes, P.mirabilis, P.aeroginosa,
E.coli,K.pneumoniae,S.fecalis. ► Complicated
skin and skin structure: due to
S.pyogenes, P.mirabilis, E.coli, S.fecalis, E.colacae. ► Intra-abdominal
infections: due to E.coli and anaerobic
Hypersensitivity to quinolones,
children or adolescents, pregnancy and
Precautions: ► Levofloxacin
may alter reactivity such as driving or
operate machinery may be impaired. ► Although
photo sensation is rare exposure to strong
sunlight or U.V is not recommended. ► False
negative results in diagnosis of T.B due to
inhibition of growth of mycobacterium
tuberculosis by Levofloxacin.
Levofloxacin should not be used in
association with iron salts, antacids,
sucralfate and theophylline.
Dosage and administration: Orally...................500 mg daily
(one tablet 500 mg once or one tablet 250 mg
twice daily). I.V. Infusion......... (500mg /
I.V. solution for infusion should be infused
slowly over a period of not less than 60
minutes for a dosage of 500 mg. N.B: I.V infusion compatible with:
0.9% Sodium chloride solution.
2.5%dextrose in Ringer solution.
In patients with renal function impairment
(creatinine clearance <50ml/min) half the
dose is given.
► Venaxan is
well tolerated. the most common adverse
reactions are nausea, abdominal discomfort,
headache & dizziness. ► Skin rashes &
photosensitivity reaction can also occur.
Keep at temp. not exceeding 30B0C
Keep out of reach of children.