Stimu-Max is an
oral therapy for erectile dysfunction. Is a
selective competitive inhibitor of cyclic
guanosine monophosphate (cGMP)-specific
phosphodiesterase type 5 (PDE5).
The physiological mechanism of erection of
the penis involves the release of nitric
oxide in the corpus cavernosum during sexual
stimulation. Nitric oxide then activates the
enzyme guanylate cyclase; which results in
increased cGMP levels, producing smooth
muscle relaxation in the corpus cavernosum
and allowing inflow of blood.
Sildenafil has no direct relaxant effect on
isolated human corpus cavernosum but he
enhances the effect of nitric oxide by
inhibiting phosphodiesterase type 5 (PDE5),
which is responsible for the degradation of cGMP in the corpus cavernosum.
When sexual stimulation causes local release
of nitric oxide, inhibition of PDE5 by
Sildenafil causes increased levels of cGMP
in the corpus cavernosum, resulting in
smooth muscle relaxation and inflow of blood
to the corpus cavernosum.
Sildenafil at recommended doses has no
effect in the absence of sexual stimulation.
Stimu-Max is rapidly absorbed, with absolute
bioavailability of about 40%.Its
pharmacokinetics are dose-proportional over
the recommended dose range.
Its eliminated predominantly by hepatic
metabolism and is converted to an active
metabolite with properties similar to the
Both Sildenafil and the metabolite have
terminal half life of about 4 hours.
Impotence (Erectile dysfunction).
Sildenafil is contraindicated with organic nitrates as it may potentiate their hypotensive effects.
Caution is required in patients with hepatic or renal impairment.
The drug shouldn't be used in patients with
pre-exiting cardiovascular diseases as there
is potential for cardiac risk of sexual activity.
The drug should be dispensed only by a
medical prescription and under strict
Dosage & route of administration & duration:
For most patients the recommended dose is 50 mg taken
as needed approximately 1 hour before sexual
activity. Based on effectiveness and
toleration, the dose may be increased to a
maximum recommended dose of 100 mg or
decreased to 25 mg.
The maximum recommended dosing frequency is
once per day.
Each tablet is scored into two halves each
contains 50 mg.
administration of Sildenafil with drugs that
inhibits cytochrome P450 isoenzyme CYP3A4 as
Cimentidine, Erythromycin, Itraconazole,
Ketoconazole and HIV protease inhibitors may
reduce Sildenafil clearance which may need a
reduction in its dose.
Stim-Max was well tolerated with recommended doses.
Dyspepsia, headache, flushing, dizziness,
nasal congestion or
priapism are rare but occasionally reported.
Keep out of the reach of children.
Keep medicine at temperature not exceeding 30°C.
Box of 5 tablets (100 mg).
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F.A.Q. about Stimu-Max Tablets