Liver damage causes changes
in the membrane of the liver cell & in this
way impairs the functional capacity of the
liver. Silymarin acts as a stabilizer of the
liver cell membrane, protects the liver
against toxic agents & restores damaged
liver cell to normal. It also stimulates
kupffer's cell & enhances protein synthesis
by acting on ribosomal R.N.A. Thus Silymarin
improves the general condition & the
digestive function. It increases appetite &
body weight & restores liver function to
normal. Silymarin is absorbed orally. A
major part of Silymarin is excreted via the
bile & passes through the enterohepatic
circulation. Silymarin is excreted mainly by
the kidney although metabolites,
particularly sulphate & glucuronide
conjugates are also present in bile.
The excretion of Silymarin in humans lasts
for about 24 hours & the total amount of
Silymarin excreted in bile is about 20-40%
of the ingested dose Only 3 - 7 % of the
total dose is excreted renally.
- In acute & chronic hepatitis.
- Liver cirrhosis to reduce its progress.Toxic metabolic liver disorders (alcoholic & diabetic liver degeneration) & other
- During administration of drugs hazardous to the liver.
No contraindications are so
far known when therapeutic doses are
Interactions with other drugs are not
Dosage and administration:
2 tablets (70 mg) 3 times daily.
1 tablet (140 mg) 3 times daily.
Keep at temperature not exceeding 30°C.
Keep medicine out of reach of children.
Box of 20 tablets 70 mg.
Box of 20 tablets 140 mg.
Box of 100 strips x 10 tablets 70mg.
Box of 100 strips x 10 tablets 140 mg.