Composition:
Amoxycillin Trihydrate (997.15 mg) Equiv. to
Amoxycillin Base 875 mg Potassium
Clavulanate (299.3 mg) Equiv. to Clavulanic
Acid Base 125 mg
Properties:
Magnabiotic is
an oral antibacterial combination of
Amoxycillin & Clavulanic acid. Amoxycillin: Is a broad spectrum semi synthetic
penicillin . Clavulanic acid:
Is a B-lactam
structurally related to Penicillins that
inactivate B-lactamase enzymes commonly
found in micro-organisms resistant to
penicillin .
The combination of Amoxycillin / Clavulanic
acid extends the antibiotic spectrum of
Amoxycillin to include bacteria normally
resistant to Amoxycillin & other B-lactam
antibiotics. Magnabiotic is well absorbed
from G.I.T after oral administration, stable
in the presence of gastric acid & may be
administered with out regard to to meals.
About 50-70 % of Magnabiotic is excreted
unchanged in urine during the first 6 hours
after oral administration . It diffuses
readily into most body tissues & fluids &
can be detected in middle ear effusion .
Contraindications:
A history of
allergic reactions to any Penicillin is a
contraindication.
Dosage & route of
administration & duration: ►Adults: For more severe infections and
infections of the respiratory tract, the
dose should be one 875-mg tablet of
Magne-Biotic Plus every 12 hours.
Patients with impaired renal function do not
generally require a reduction in dose unless
the impairment is severe.
Warning:
Hepatically impaired
patients should be dosed with caution and
hepatic function monitored at regular
intervals.
Side effects:
Magnabiotic is
generally well tolerated. The majority of
side effects are mild & transient and
consist mainly of
diarrhea,
nausea,
abdominal discomfort, skin rashes &
urticaria which disappear upon
discontinuation of therapy.
Storage:
Keep in a cool
dry place at temp. less than 25ºC.
Keep medicine out of reach of children.
Amoxycillin Trihydrate (997.15 mg) Equiv. to
Amoxycillin Base 875 mg Potassium
Clavulanate (299.3 mg) Equiv. to Clavulanic
Acid Base 125 mg