Composition: Each tablet
a derivative of benzimidazole that possesses
both prokinetic and ant emetic properties.
Domperidone is a dopaminergic antagonist, it
increases the basal lower esophageal
sphincter pressure, inhibits relaxation of
the gastric fundus, enhances antral
contractility & relax pyloric sphincter.
Domperidone is absorbed after oral
administration, and is excreted in the
feaces and urine mainly as metabolites.
The half life time is about 7-8 hours.
Domperidone is not generally considered to
cross the blood brain barrier and this
excludes psychotropic and neurological side
Indications: ►Nausea and
vomiting of various origins (functional,
infectious, organic or dietic) and those
induced by radiotherapy or drug therapy
Domperidone is extremely
Contra-indications: ► There are no
known absolute contraindications ► The
anti-cholinergic drugs antagonist the effect
of Domperidone. ► Raised serum
prolactin levels have been observed but
these drop to normal when the treatment is
discontinued. ► The drug is
avoided during pregnancy due to insufficient
Precautions: Not give the medicine: ► To
patients Impaired liver patients ► To
patients with existing abnormalities of
electrical activities in heart or heart
rhythm. ► Not
used with other medicines with similar
effect on heart ► Not
used with medicine which increase
Dosage and administration: ►In
nausea and vomiting 1 tablets (10 mg) 3 time daily (ONE week
cramps have been reported in rare cases and
Keep your tablets in the pack in which they were supplied.
Keep your tablets below 30°C.
Keep your tablets in a safe place where children cannot see or reach them.