Composition: Each tablet
contains:
Domperidone ……………….10mg
Properties:
Domperidone is
a derivative of benzimidazole that possesses
both prokinetic and ant emetic properties.
Domperidone is a dopaminergic antagonist, it
increases the basal lower esophageal
sphincter pressure, inhibits relaxation of
the gastric fundus, enhances antral
contractility & relax pyloric sphincter.
Domperidone is absorbed after oral
administration, and is excreted in the
feaces and urine mainly as metabolites.
The half life time is about 7-8 hours.
Domperidone is not generally considered to
cross the blood brain barrier and this
excludes psychotropic and neurological side
effects.
Indications: ► Nausea and
vomiting of various origins (functional,
infectious, organic or dietic) and those
induced by radiotherapy or drug therapy ► Gastrointestinal
disorders due to delayed gastric emptying ►Gastro-
Esophageal Reflux ► Esophagitis,
such as sensation of fullness. ► Upper
abdominal pain ► Eructation ►Flatulence. ►Heartburn
with or without regurgitation of gastric
contents
Domperidone is extremely
selective:
Contra-indications: ► There are no
known absolute contraindications ► The
anti-cholinergic drugs antagonist the effect
of Domperidone. ► Raised serum
prolactin levels have been observed but
these drop to normal when the treatment is
discontinued. ► The drug is
avoided during pregnancy due to insufficient
human studies.
Dosage and administration: ►In
nausea and vomiting 2 tablets (20 mg) 3-4 time daily. ►In
gastrointestinal disorders 1 tablet (10 mg) 3 time daily preferably
15-30 minutes before meals (if necessary one
tablet is given before bed time)
This dose can be doubled when required.
Side effects:
Mild abdominal
cramps have been reported in rare cases and
usually transit.
Storage:
Keep your tablets in the pack in which they were supplied.
Keep your tablets below 30°C.
Keep your tablets in a safe place where children cannot see or reach them.
