Composition:
Urokinase I.U .... 100,000 or 250,000 or 500,000 I.U.

Properties:
Angikinase is indicated in cases of:
► Pulmonary embolism
► Coronary artery thrombosis and myocardial infarction
► Deep venous thrombosis (or venous thrombo-embolism)
► Peripheral arterial thrombo-embolism
► Some cases of peritonitis.

Dosage and administration:
► In cases of Pulmonary Embolism and Deep Venous Thrombosis:

Priming infusion dose	4400 IU/ Kg at a rate of 90 ml /hr
Followed by
Continuous infusion dose	4400 IU Kg at a rate of 15 ml / hr over a period of 12 hrs

Coronary artery Thrombosis and Myocardial Infarction:
► Intracoronary Route:
Before the administration of urokinase prior bolus 2500 – 10,000 Units of heparin should be administered through intravenous administration.
Reconstitute three vials of Angikinase 250,000 IU by aseptically adding 5 ml of sterile water for injection.
Then Angikinase is infused at a rate of 4ml /min into the occluded artery for a period up to 2 hours.

► Intravenous route:
Angikinase is also administered at doses of 2 -3million units over 45 – 90 minutes.

Peripheral arterial- thromboembolism:
Urokinase is infused in the clot via a catheter at a rate of 4000 IU / min and the catheter is advanced every 2 hours till flow is resumed. then at a rate of 1000 IU / min till complete clot lysis occurs.

N.B: Preparation of reconstituted material
1. it is important to reconstitute only with sterile water for injection for injection without preservatives
2. Do not use bacteriostatic water for injection.
3. To minimize the formation of filaments avoid shaking the vial during reconstitution. Only Roll and tilt the vial during reconstitution.
4. Do not add other medications to the solution.
5. Because urokinase contains no preservatives do not reconstitute until immediately before use.
6. Discard any unused portion of the reconstituted material.

Warning:
Keep your tablets in the pack in which they were supplied.
Keep your tablets below 30°C.
Keep your tablets in a safe place where children cannot see or reach them.

Packing:
Box containing one vial of urokinase 100,000, 250,000 and 500,000 IU