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Acetaminophen
(Suppositories Pediatric)    

Composition:
Each suppository contains:
Paracetamol ................................. 0.125 gm

Properties:
Paracetamol is the principal active metabolite of phenacetin & acetanilide, but is associated with less toxicity. Paracetamol reduces fever by direct action on the hypothalamus heat-regulating centers. Paracetamol is almost as potent as aspirin in inhibiting prostaglandin synthetase in the CNS, but its peripheral inhibition of prostaglandin synthesis is minimal, Paracetamol exerts a strong analgesic effect by raising the threshold of response to pain stimuli .Generally the antipyretic & analgesic effects of Paracetamol & aspirin are comparable, but Paracetamol does not inhibit platelet aggregation, affect prothrombin response or produce GI ulceration.

Indications:
Fever of various etiologies.
Pain of various origins.
Common cold, influenza & other febrile conditions.
As analgesic & antipyretic in the presence of aspirin allergy, haemostatic disturbances (including anticoagulant therapy) bleeding diatheses, upper GI disease.

Adverse effects:
Used as directed Paracetamol rarely causes side effects however skin eruptions or hematological reactions may occur.
Over dosage might produce symptoms such as vomiting, gastrointestinal disturbances, renal or liver affection.

Storage:
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.

Presentation:
Box of 5 suppositories.

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