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Composition:
Each tablet contains:
Citalopram Hydrobromide ............ Equivalent to 20 mg citalopram
Properties:
Citalopram is a
selective serotonin reuptake inhibitor (SSRI) which plays an essential role in
treatment of depression and other
psychological disorders.
Citalopram is readily absorbed from
gastro-intestinal tract, and maximum plasma
concentrations are reached 2 to 4 hours
after oral administration, and its protein
binding is low.
Citalopram is metabolized by demethylation,
deamination and oxidation to inactive
metabolites. It is excreted in the urine and
feaces.
Indications:
► Mood
Disorders: various degrees of depression,
unipolar or dipolar mania, major or minor
disorders
► Neurotic
disorders :as anxiety, phobia, and obsessive
compulsive disorders (OCD)
► Disturbed
behavior & conduct disorders.
► Eating
disorders :anorexia nervosa, bulimia
nervosa.
Contra-indications:
► Hypersensitivity
to the drug.
► Concomitant
use in patients taken monoamine oxidase
inhibitors ( MAOI's )
► Sever liver
dysfunction.
► Uncontrolled
cases of diabetes or epilepsy and history of
suicidal attempts.
Drug interactions:
Caution should
be taken when the drug is taken in
combination with somatriptan, warfarin,
carbamazepine, omeprazole, cimetedine,
metoprolol beta blocker ,erythromycin and
tricyclic antidepressants.
Precautions:
The drug should be used with patients with
liver functions
impairement, diabetes, epilespy and suicidal
tendencies.
Use during pregnancy & lactation:
The drug is contraindicated during pregnancy
and lactation.
Dosage and administration:
20 to 60 mg daily (the dose should be
gradually increased from 20 mg according to
the response of each dose)
Side effects:
► Gastro-intestinal
disturbances as nausea, vomiting, dyspepsia
and diarrhea.
► Anorexia and
weight loss can be occurs.
► Neurological
side effects as insomnia, fatigue or
tremors.
► Sexual
dysfunction may occurs.
Packing:
Box of 7 or 14 tablets.
Serotonin and Sedopram (PowerPoint)
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