Citalopram is a
selective serotonin reuptake inhibitor (SSRI) which plays an essential role in
treatment of depression and other
Citalopram is readily absorbed from
gastro-intestinal tract, and maximum plasma
concentrations are reached 2 to 4 hours
after oral administration, and its protein
binding is low.
Citalopram is metabolized by demethylation,
deamination and oxidation to inactive
metabolites. It is excreted in the urine and
- Mood Disorders: various degrees of depression,unipolar or dipolar mania, major or minor disorders
- Neurotic disorders :as anxiety, phobia, and obsessive compulsive disorders (OCD)
- Disturbed behavior & conduct disorders.
- Eating disorders :anorexia nervosa, bulimia nervosa.
- Hypersensitivity to the drug.
- Concomitant use in patients taken monoamine oxidase inhibitors ( MAOI's )
- Sever liver dysfunction.
- Uncontrolled cases of diabetes or epilepsy and history of suicidal attempts.
be taken when the drug is taken in
combination with somatriptan, warfarin,
carbamazepine, omeprazole, cimetedine,
metoprolol beta blocker , erythromycin and
The drug should be used with patients with
impairement, diabetes, epilespy and suicidal
Use during pregnancy & lactation:
The drug is contraindicated during pregnancy
Dosage and administration:
20 to 60 mg daily (the dose should be
gradually increased from 20 mg according to
the response of each dose)
- Gastro-intestinal disturbances as nausea, vomiting, dyspepsia and diarrhea.
- Anorexia and weight loss can be occurs.
- Neurological side effects as insomnia, fatigue or tremors.
- Sexual dysfunction may occurs.
Box of 7 or 14 tablets.
Serotonin and Sedopram (PowerPoint)