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Acefylline
(Injection)    

Composition:
Each 5 ml ampoule contains:
Acefylline piperazine ................................. 500 mg.

Properties:
Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation.

Indications:
Asthma, emphysema, acute and chronic bronchitis associated with bronchospasm
Chronic inflammatory lung diseases.
Inhalation of irritants.

Use in pregnancy:
Safety is not established.

Drug interactions:
Xanthenes derivatives may:
Produce excessive C.N.S. Stimulation when given with ephedrine or other sympathomimetic specially in children (In the very
    young) convulsions may occur.
Enhance the toxicity of digitalis glycosides
The bronchodilator action of xanthenes may be antagonized by beta adrenergic blockers and reduced by smoking
Tachycardia may occur when xanthenes are given with reserpine or sympathomimetic
Increased serum levels and effects of xanthenes derivatives may occur with erythromycin.lincomycin, clindamycin and
    allopurinol.

Precautions:
The dose should not be exceeded in children especially neonates
Use with caution in cases of:
compromised cardiac or circulatory function, hyperthyroidism, prostate hypertrophy, peptic ulcer, glaucoma, diabetes mellitus, severe hypertension and in nursing mothers.

Contraindications:
Hypersensitivity to xanthenes
Severe renal or hepatic impairment
Gastritis and active peptic ulcer
Rapid cardiac arrhythmias and acute coronary heart disease when myocardial stimulation.
Might be harmful.

Dosage & route of administration & duration:
The optimum therapeutic serum concentration is considered to range from 10 to 20 mcg/ml
To avoid adverse effects the rate of infusion administration should not exceed 20 mg / min
For I.M & slow I.V injection of 200 mg over at least 15 min.
For IV infusion a loading dose of 4 mg/kg may be given over 20 to 30 min followed by a suggested maintenance dose of 0.5 mg /kg / hour reduced after 12 hours to 0.4 mg/kg/hour.

Suggested Doses for children:
4mg/Kg by slow IV injection over at least 15 min or by infusion with a loading dose of 4 mg/kg followed by maintenance doses of:
Children from 6 months to 6 years...................0.8 to 1 mg/kg/hour, reduced after the first 12 hours to 0.6 mg/kg/hour.
Children over 6 years.....................................0.75 mg/kg/hour, reduced after the first 12 hours to 0.5 mg/kg/hour.

Adverse effects:
Gastrointestinal disturbance: epigastria pain, nausea, vomiting and diarrhea.
C.N.S. stimulation: irritability (Specially in children), nervousness, insomnia & headache.
Palpitations, tachycardia and extra systole.
Tachypnea.
Transient urinary frequency.

Storage:
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.

Presentation: Box of 100 ampoules.

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