Each 5 ml ampoule contains:
Acefylline piperazine ................................. 500 mg.
Acephylline piperazine is a theophylline derivative with
a direct bronchodilator action. It has the
advantages over theophylline in being far
less toxic and producing minimal gastric
bronchitis associated with
Chronic inflammatory lung diseases.
Inhalation of irritants.
Use in pregnancy:
Safety is not established.
Xanthenes derivatives may:
excessive C.N.S. Stimulation when given with
ephedrine or other sympathomimetic specially
in children (In the very young) convulsions
- Enhance the toxicity of digitalis glycosides
- The bronchodilator action of xanthenes may be
antagonized by beta adrenergic blockers and
reduced by smoking
- Tachycardia may occur when xanthenes are given with
reserpine or sympathomimetic
serum levels and effects of xanthenes
derivatives may occur with
erythromycin.lincomycin, clindamycin and allopurinol.
The dose should not be
exceeded in children especially neonates
Use with caution in cases of:
compromised cardiac or circulatory function,
hyperthyroidism, prostate hypertrophy,
peptic ulcer, glaucoma, diabetes mellitus,
severe hypertension and in nursing mothers.
Dosage & route of
administration & duration:
- Hypersensitivity to xanthenes
- Severe renal or hepatic impairment
- Gastritis and active peptic ulcer
- Rapid cardiac arrhythmias and acute coronary heart disease when myocardial stimulation.
- Might be harmful.
The optimum therapeutic
serum concentration is considered to range
from 10 to 20 mcg/ml
To avoid adverse effects the rate of
infusion administration should not exceed 20
mg / min
For I.M & slow I.V injection of 200 mg over
at least 15 min.
For IV infusion a loading dose of 4 mg/kg
may be given over 20 to 30 min followed by a
suggested maintenance dose of 0.5 mg /kg /
hour reduced after 12 hours to 0.4
Suggested Doses for children:
4mg/Kg by slow IV injection over at least 15
min or by infusion with a loading dose of 4
mg/kg followed by maintenance doses of:
- Children from 6 months to 6 years
0.8 to 1 mg/kg/hour, reduced after the first 12 hours to 0.6
- Children over 6 years
0.75 mg/kg/hour, reduced after the first 12 hours to 0.5 mg/kg/hour.
- Gastrointestinal disturbance: epigastria pain, nausea, vomiting and diarrhea.
- C.N.S. stimulation: irritability (Specially in children), nervousness, insomnia & headache.
- Palpitations, tachycardia and extra systole.
- Transient urinary frequency.
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.
Box of 100 ampoules.