How does Angikinase SEDICO is administrated?
Angikinase SEDICO is simply administrated as follow:
The vial is reconstituted in 5 ml saline or sterile water and then diluted in normal saline and given as:

Priming infusion dose	4400 IU / kg at rate of 90 ml / h over 10 minutes
Followed by
Continuous infusion dose	4400 IU/ kg / hour at a rate of 15 ml each hour for 12 - 24 hours

What are the clinical applications of Angikinase SEDICO (Urokinase 500.000 IU)?
Angikinase SEDICO is used clinically as a thrombolytic agent in the treatment of:
► Pulmonary embolism
► Severe or massive deep venous thrombosis
► Recurrent coronary artery thrombosis and Myocardial infarction
► Peripheral arterial thrombo-embolism
► Some cases of peritonitis
► Occluded intravenous or dialysis cannulas

It is also administered intrapleurally to improve the drainage of complicated pleural effusions and empyemas.

Simply, How does Angikinase SEDICO (Urokinase 500.000 IU) work?

Fibrinolysis: Urokinase mode of action.

Does Angikinase SEDICO effective?
Angikinase SEDICO shows significant reduction of mortality and recurrence of PE:

Konstantinides et Al, 1997

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