What is meant by Amebiasis?
Amebiasis is a
parasitic infection caused by Entamoeba
histolytica. Amebiasis is an intestinal
infection that may or may not be
symptomatic. When symptoms are present it is
generally known as invasive Amebiasis.
How does Amebiasis Transmit?
Amebiasis is usually transmitted by contamination of
drinking water and foods with fecal matter,
but it can also be transmitted indirectly
through contact with dirty hands or objects
as well as by sexual intercourse
How to prevent infection with Amebiasis?
Wash hands thoroughly with soap before handling food
Good Washing for vegetables and fruits
Pay attention to toilet seats and taps
Does Amebiasis has symptoms & if so what are these symptoms?
Amebiasis may be symptomatic and may be not.
Amebiasis symptoms take from a few days to a
few weeks to develop and manifest
themselves, but usually it is about two to
four weeks. Symptoms can range from mild
diarrhea to dysentery with blood and mucus
Infections the amoeba lives by eating and
digesting bacteria and food particles in the
gut. It does not usually come in contact
with the intestine itself due to the
protective layer of mucus that lines the
gut. Disease occurs when amoeba comes in
contact with the cells lining the intestine.
It then secretes the same substances it uses
to digest bacteria, which include enzymes
that destroy cell membranes and proteins.
This process leads to penetration and
digestion of human tissues, resulting first
in flask-shaped ulcers in the intestine.
Entamoeba histolytica ingests the destroyed
cells by phagocytosis and is often seen with
red blood cells inside
N.B Absence of symptoms or their intensity
may vary with such factors as strain of
amoeba, immune response of the host, and
perhaps associated bacteria and viruses
How does treatment of Amebiasis occur?
Two different sorts of drugs are needed to rid the body of
the infection, one for each location.
Metronidazole, is used to destroy ameba
that have invaded tissue. It is rapidly
absorbed into the bloodstream and
transported to the site of infection.
Because it is rapidly absorbed there is
almost none remaining in the intestine.
Paromomycin or diloxanide furoate is used
since most of the amebae remain in the
intestine when tissue invasion occurs, it is
important to get rid of those also or the
patient will be at risk of developing
another case of invasive disease.
Therfore first we use Metronidazole then we
use paromomycin or diloxanide furoate.