Spiromide
(Tablets)
  • Spiromide tablets
  • Composition:
    Each tablet of Spiromide 50 mg contains:
    Spironolactone ........................... 50 mg
    Furosemide ............................... 20 mg

    Each tablet of Spiromide 100 mg contains:
    Spironolactone .......................... 100 mg
    Furosemide ............................... 20 mg
Properties:
Spiromide is a combination of two potent diuretics (spironolactone and Furosemide):
  • Spironolactone acts specifically to inhibit aldosterone action on the distal tubules.
  • Furosemide exerts its action over the loop of Henle, as well as the proximal & distal tubules to a lesser extent, both actions result in excretion of sodium and water.
  • In addition, spironolactone minimizes loss of potassium in urine.

Indications:
Edema associated with congestive heart failure, nephrotic syndrome, liver cirrhosis with ascites, idiopathic edema, essential hypertension.

Contraindications:
  • Anuria.Anuria, sometimes called anuresis, is nonpassage of urine
  • Hypotension.
  • Significant renal impairment.
  • Hepatic coma.
Precautions:
  • Symptoms &signs of fluid & electrolyte imbalance should be observed: dry mouth, thirst, lethargy, restlessness, muscle pain, fatigue,nausea & vomiting
  • Spiromide reduces the vascular responsiveness to nor adrenaline therefore caution should be taken in managing patients subjected to anesthesia while being treated with Spiromide.
  • Spiromide increases the half-life of digitalis, resulting in possible digitalis toxicity. The dose of digitalis should be reduced accordingly.
  • Spiromide may raise BUN levels and cause mild acidosis in patients with impaired renal function.

Use during pregnancy and lactation:
Spiromide is better avoided during pregnancy and lactation Use only if the potential benefit justifies potential risk to the fetus or child.

Warning:
Sudden alteration of fluid & electrolyte balance in patients with hepatic impairment may precipitate hepatic coma. Strict observation is necessary.
Furosemide was found to cause toxicity if taken with amino-glycosides or with renal impairment.
Excess diuresis may cause dehydration and reduction in blood volume with circulatory collapse especially in elderly people.

Dosage & route of administration & duration:
1-2 tablets daily

Side effects:
Side effects are reversible after stoppage of drug use. They include symptoms of electrolyte disturbance, nausea, vomiting, abdominal colic, tinnitus, headache, vertigo & blurred vision. Anemia, leukopenia, allergic reactions, hypocalcaemia, hyperuricemia & Glycosuria have been reported. Gynecomastia may occur.

Storage:
Keep at temp. not exceeding 30°C
Keep medicine out of reach of children

Presentation:
Box of 10 tablets (50mg)
Box of 10 tablets (100mg)