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 Composition:
Each tablet of Spiromide 50 mg contains:
Spironolactone ........................... 50 mg
Furosemide ............................... 20 mg
Each tablet of Spiromide 100 mg contains:
Spironolactone .......................... 100 mg
Furosemide ............................... 20 mg
Properties:
Spiromide is a combination of two potent diuretics (spironolactone and Furosemide):
► Spironolactone acts specifically to inhibit aldosterone action on the distal tubules.
► Furosemide
exerts its action over the loop of Henle, as
well as the proximal & distal
tubules to a
lesser extent, both actions result in
excretion of sodium and water.
In addition, spironolactone minimizes loss
of potassium in urine.
Indications:
Edema associated with congestive heart failure,
nephrotic syndrome, liver cirrhosis with
ascites, idiopathic edema, essential
hypertension.
Contraindications:
► Anuria.
► Hypotension.
► Significant renal impairment.
► Hepatic coma.
Precautions:
► Symptoms &
signs of fluid & electrolyte imbalance
should be observed: dry mouth, thirst,
lethargy, restlessness, muscle pain
&
fatigue,
nausea & vomiting.
► Spiromide
reduces the vascular responsiveness to nor
adrenaline therefore caution should be taken
in managing patients
subjected to anesthesia
while being treated with Spiromide.
► Spiromide
increases the half-life of digitalis,
resulting in possible digitalis toxicity.
The dose of digitalis should be reduced
accordingly.
► Spiromide may
raise BUN levels and cause mild acidosis in
patients with impaired renal function.
Use during pregnancy and lactation:
► Spiromide is
better avoided during pregnancy and
lactation Use only if the potential benefit
justifies potential risk to the fetus
or
child.
Warning:
Sudden alteration of fluid & electrolyte balance in
patients with hepatic impairment may
precipitate hepatic coma. Strict observation
is necessary.
Furosemide was found to cause ototoxicity if
taken with amino-glycosides or with renal
impairment.
Excess diuresis may cause dehydration and
reduction in blood volume with circulatory
collapse especially in elderly people.
Dosage & route of administration & duration:
1-2 tablets daily
Side effects:
Side effects are reversible after stoppage of drug use.
They include symptoms of electrolyte
disturbance, nausea, vomiting, abdominal
colic, tinnitus, headache, vertigo & blurred
vision. Anemia, leukopenia, allergic
reactions, hypocalcaemia, hyperuricemia &
Glycosuria have been reported. Gynecomastia
may occur.
Storage:
Keep at temp. not exceeding 30°C
Keep medicine out of reach of children
Presentation:
Box of 10 tablets (50mg)
Box of 10 tablets (100mg)
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