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Salbutamol
(Tablets & Syrup)

Composition:
Each tablet contains:
Salbutamol ………………… 2 mg
Each 5 ml of syrup contains:
Salbutamol ………………… 2 mg

Properties:
Salbutamol is a B2 adrenergic drug that stimulates adenyl cyclase the enzyme which catalyzes the formation of cyclic AMP from ATP.The cyclic AMP thus formed mediates the cellular responses. Salbutamol exerts direct & preferential action on beta 2 adrenoreceptors including those of the bronchial tree & uterus.
Salbutamol is readily absorbed from the G.I. tract. It is subject to first - pass metabolism in the liver, about a half is excreted in the urine as an inactive sulphate conjugate, following oral administration (the rest being unchanged Salbutamol) The plasma half life has been estimated to range from about 2 to as much as 7 hours. In general the intermediate values have followed oral administration .

Indications:
For the relief of bronchospasm in patients with reversible obstructive airway disease e.g. bronchial asthma, bronchitis ………., etc.

Contra-indications:
The drug is contraindicated in patients with a history of hypersensitivity to Salbutamol.

Precautions:
Salbutamol should be used with caution in patients with cardiovascular disorders, in patients with hyperthyroidism or diabetus mellitus & in patients who are unusually responsive to sympathomimetic amines
Use during pregnancy & in nursing mothers:
Salbutamol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Drug interactions:
The concomitant use of Salbutamol & other oral sympathomimetic agents is not recommended since such combined use may lead to deleterious cardiovascular effects. Salbutamol should be administered with extreme caution to patients being treated with M.A.O. inhibitors or tricyclic antidepressants since the action of Salbutamol on the vascular system may be potentiated. Beta-receptor blocking agents & Salbutamol inhibit the effect of each other.

Dosage and administration:
Adults:
One or two tablets 3 - 4 times daily.

Elderly & sensitive patients:
One tablet 3 - 4 times daily.

Children:
Children Under 2 years:
100 micrograms / 1 kg / 4 times daily.
2 - 6 years :
I - 2 mg (half - one teaspoonful) 3 - 4 times daily
6 -12 years:
2 mg (one teaspoonful) 3 - 4 times daily.

Side effects:
Salbutamol may cause fine tremors of skeletal muscles, palpitations& muscle cramps Slight tachycardia, tenseness, headache, peripheral vasodilatation & hypokalaemia have been reported after large doses

Overdosage:
Manifestations of over dosage include anginal pain, hypertension & exaggeration of the effects listed in side effects. Treatment consists of discontinuation of Salbutamol together with appropriate symptomatic treatment.

Storage:
Keep at temp. not exceeding 30°C .
Keep medicine out of the reach of children.

Packing:
Box of 20 tablets
Bottle of 120 ml .

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