Each 5 ml
Metronidazole benzoate ............ 200 mg(
eq. to metronidazole .......... 125 mg)
Metronidazole is active against various
anaerobric bacteria and protozoa
Metronidazole enters the target cell , where
its nitro group is reduced . Unstable
intermediate compounds are formed which bind
to D.N.A and inhibit synthesis causing cell
Metronidazole is active against anaerobic
gram negative and gram positive bacilli ,
anaerobic gram positive cocci .
Metronidazole is well absorbed after oral
administration & peak serum levels occur
after 2 hours .
Metronidazole has a large apparent volume
distribution it diffuses well into all
tissues achieving therapeutic levels .
Metronidazole elimination is via urine
mainly ( 60 to 80 % ) and the rest is
fecally eliminated .
► Peritonitis .
abscess and liver abscess .
► Hypersensitivity to metronidazole or other
nitromidazole derivatives .
► First trimester of pregnancy.
Gastrointestinal disturbances like nausea,
unpleasant metallic taste,
diarrhea & dry mouth may occur.
Urethral discomfort & darkening of the urine
has been reported.
Dosage & route of
administration & duration:
intestinal amebiasis & amebic liver abscess
in adults : 500 - 750 mg 3 times / day
for 5 - 10 days .
in children : 35 - 50 mg / kg / day in 3
divided doses .
& giardiasis :
in adults one day treatment 2 gm, given
as a single dose or in 2 divided doses .
7 day course treatment .
Adults : 250 mg 3 times daily for 7
Children : 5 mg / kg / dose 3 times for 7
Oral metronidazole follows IV therapy when
The usual adult oral dose is 7.5 mg / kg
every 6 hours . Do not exceed a maximum of 4
g in 24 hours.
Children : 20 to30 mg / kg / day .
N.B.: Shake the bottle well before
Keep at temp. not exceeding 30ºC
Keep out of reach of children.
Bottle of 120