Metronal
(Oral suspension)

Composition:
Each 5 ml contains :
Metronidazole benzoate ............ 200 mg
( eq. to metronidazole .......... 125 mg)

Properties:
Metronidazole is active against various anaerobric bacteria and protozoa
Metronidazole enters the target cell , where its nitro group is reduced . Unstable intermediate compounds are formed which bind to D.N.A and inhibit synthesis causing cell death .
Metronidazole is active against anaerobic gram negative and gram positive bacilli , anaerobic gram positive cocci .
Metronidazole is well absorbed after oral administration & peak serum levels occur after 2 hours .
Metronidazole has a large apparent volume distribution it diffuses well into all tissues achieving therapeutic levels .
Metronidazole elimination is via urine mainly ( 60 to 80 % ) and the rest is fecally eliminated .

Indications:
  • Amebiasis.
  • Symptomatic trichomoniasis.
  • Asymptomatic trichomoniasis.
  • Peritonitis.
  • Intraabdominal abscess and liver abscess .
Contraindications:
  • Hypersensitivity to metronidazole or other nitromidazole derivatives .
  • First trimester of pregnancy.

Side effects:
Gastrointestinal disturbances like nausea, unpleasant metallic taste, diarrhea & dry mouth may occur.
Urethral discomfort & darkening of the urine has been reported.

Dosage & route of administration & duration:
  • Acute intestinal amebiasis & amebic liver abscess:
    in adults : 500 - 750 mg 3 times / day for 5 - 10 days .
    in children : 35 - 50 mg / kg / day in 3 divided doses .
  • Trichomoniasis & giardiasis :
    in adults one day treatment 2 gm, given as a single dose or in 2 divided doses , 7 day course treatment .
    Adults : 250 mg 3 times daily for 7 consecutive days.
    Children : 5 mg / kg / dose 3 times for 7 consecutive days.
  • Anaerobic bacterial infections:
    Oral metronidazole follows IV therapy when conditions warrant.
    Adult : oral dose is 7.5 mg / kg every 6 hours . Do not exceed a maximum of 4 g in 24 hours.
    Children : 20 to30 mg / kg / day .
    N.B.: Shake the bottle well before use.

Storage:
Keep at temp. not exceeding 30ºC
Keep out of reach of children.

Presentation:
Bottle of 120 ml .