Composition:
Each capsule contains:
Fluconazole ........................150 mg.
Or
Fluconazole...........................50 mg.

Properties:
► Fluconazole is a diflurophenyl bis triazole tertiary alcohol which has a broad spectrum antifungal activity.
► Flucoral is very well absorbed from the GIT even in the presence of food, antacids or H2 receptor antagonist pretreatment.
► After oral administration plasma levels are nearly as high as intravenous administration.
► Flucoral is widely distributed in tissues & body fluids.
► Concentrations in c.s.f,saliva,sputum, vaginal fluid approximate those attained in the plasma.
► Oral bioavailability exceeds 90% in contrast to other anoles antifungal which are highly protein bound.
► Flucoral is only 11% protein bound.
► The drug is excreted mainly in the urine.
► Elimination half-life is approximately 30 hours.

Indications:
► Oropharyngeal,esophageal & vaginal Candidiasis.
► Fungal infections of the skin & nail due to Candida or dermatophytes.
► Serious systemic candidal infections including, urinary tract infections,peritonitis,penurhonia & Cryptococcus meningitis.
► For the prophylaxis of fungal infections in immuno-compromised patients.

Contraindications:
Is contraindicated in patients who have shown hypersensitivity to Fluconazole or in case of acute impaired liver functions.

Precautions:
► In patients who develop liver function abnormalities or skin rash treatment should be discontinued.
► Flucoral may be used in pregnancy only in life threatening infections and if the potential benefit justifies the possible risk to the fetus. The use of Flucoral in nursing mothers is not recommended

Dosage and administration:
► Vaginal Candidacies : single oral dose of 150 mg ( one capsule) is given.
► Coetaneous fungal infections : same as above, & treatment is repeated after one week. A third or fourth dose on the third or fourth week may be needed in very few cases.
► Pharyngeal & Esophageal Candidacies : A daily dose of 150 mg (one capsule) is given.
► Serious systemic Candidacies & Cryptococcus meningitis : Start with a loading dose of 2-3 capsules is given i.e. 300-450 ml. The a daily therapy of 1-2 capsules 150 - 300 mg , treatment is continued according to response.

N.B
► In patients with impaired renal functions : full dosage of creatinine clearance exceeds 0.8 ml/sec is recommended.
► Half dosage if creatinine clearance is 0.35 - 0.8 ml/sec is recommended.
► One quarter dosage if creatinine clearance is 0.18 - 0.35 ml/sec is recommended.

Side effects::
Flucoral is very well tolerated, nausea, headache, abdominal discomfort may occur. Occasionally abnormalities of liver enzymes. As with other anoles anaphylaxis has been rarely reported.

Storage:
Keep at temperature not exceeding 30°C

Packing:
Box of 2 capsules.(150 mg Fluconazole)
Box of 6 capsules. (50 mg Fluconazole)