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Composition:
Each tablet contains:
Glimepiride...................1mg, 2mg or
3mg.
Properties:
Glimepiride is an oral
hypoglycemic drug of the Sulfonylurea class.
It lowers blood glucose levels by
stimulating the release of insulin from
functioning pancreatic beta cells & also by
increasing the sensitivity of peripheral
tissues to insulin.
Diabride is totally absorbed from the GIT
within 1 hour, with peak drug levels at 2 -
3 hours
Indications:
► Non insulin dependent
diabetes mellitus ( NIDDM) not responding to
diet & exercise alone.
► In combination with insulin in patients
whose glucose levels cannot be controlled by
diet, exercise, & oral hypoglycemic agents
alone.
Contraindications:
► Hypersensitivity to the drug
► Diabetic ketoacidosis, with or without
comma.
Precaution:
► Hypoglycemia :
All sulfonylureas are capable of producing
hypoglycemia, proper patient selection,
dosage & instructions are important .
► Loss of
control of blood glucose, when a patient is
exposed to stress as fever, trauma,
infection, or surgery , loss of control of
blood glucose may occur. It should be
necessary to add insulin to Diabride or even
use insulin monotherapy.
Use during
pregnancy & Lactation :
Diabride should
not be used during pregnancy as it may cause
congenital abnormalities. It is also not
recommended to use during lactation. It is
advised that insulin be used during
pregnancy & lactation to maintain glucose
levels as close to normal as possible.
Adverse Effects:
► Nausea,
vomiting, gastrointestinal pain,&
diarrhea
have been rarely reported.
► Dizziness,
pruritus, erythema &
urticariaoccur in less
than 1 % .
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