Composition: |
|
Each tablet
contains:
Acetyl salicylic acid ( Aspirin
).........................75 mg |
| Properties: |
Acetyl salicylic acid has
analgesic ‚ antipyretic and anti
inflammatory properties .It inhibits
prostaglandins biosynthesis by inhibition of
cyclo - oxygenase enzyme, achieving these
effects. It also has an antiplatelet action
by inhibition of thromboxane A2 - an inducer
of platelet aggregation on the arterial side
of the circulation.
|
| Indications: |
►Prophylaxis
of cerebrovasular disease and myocardial
infection.
►Pediatric
analgesic, antipyretic, juvenile arthritis.
|
| Drug interaction: |
►NSAIDS
: Avoid concurrent administration which
results in increased side effects.
►Anticoagulants
: increase risk of bleeding due to
antiplatelet effect.
►Antiepileptic
: enhanced effects of phenytoin and
valoproate.
►Corticosteroids
: Increased risk of gastrointestinal
bleeding and ulceration.
►Antacids
and adsorbents : excretion of aspirin
increases in alkaline urine.
►Cytotoxics
: reduced excretion of methotrexate
(increased toxicity(
►Diuretics :
antagonism of the diuretic effect of
spironolactone, reduced excretion of
acetazolamide (risk of toxicity
►Metoclopramide
: enhances the effect of aspirin
(increased rate of absorption(
|
| Contraindications: |
►Known
hypersensitivity to Aspirin.
►Hemophilia and
other hemorrhagic disorders.
►Children under
12 years (except cases of juvenile
arthritis(
►Gastrointestinal
ulceration.
►Pregnancy:
Concerning the harmful effect of Aspirin
in the last three months of pregnancy due to
the possibility of prolonging the period of
pregnancy and the increased risk of
antepartum and postpartum hemorrhage as well
as risk of bleeding tendency in the new
born, it must not be used in high doses
during the last 3 months of pregnancy
►Breast
feeding.
|
| Precautions: |
►Acetyl
salicylic acid should be taken cautiously in
patients prone to dyspepsia or known to have
a lesion of the gastric mucosa.
►Renal &
hepatic impairment.
►Asthmatic
patients.
►G6 PD
deficiency ( Glucose 6 phosphate
dehydrogenase(
|
| Dosage & route of
administration & duration: |
For Adults:
Cerebrovasular
disease.....................................................
75 - 300 mg daily
Myocardial
infarction.........................................................150
- 300 mg daily.
For children:
not less than 12 years (except juvenile
arthritis).................. 65 mg / kg /
daily.
N.B.: Aspirin must be taken after meals.
|
| Adverse
effects: |
►Gastrointestinal
disturbances are the most common side
effects.
►Some persons
especially asthmatics exhibit notable
sensitivity to aspirin.
►The drug
increases the bleeding time, decreases
platelet adhesiveness & in large doses, may
cause hypo pro-thrombinemia.
|
| Storage: |
Keep at temp. not exceeding
30°C.
Keep medicine out of the reach of children.
|
| Presentation: |
Box of 2O tablets or 50
tablets.
|
