Composition:
Each capsule contains
Azithromycin ........................ 250 mg or 600 mg

Each 5 ml of reconstituted suspension contains
Azithromycin ........................ 200 mg

Properties:
Azithromycin is an azalide, a subclass of macrolide antibiotics and is derived from erythromycin. Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis and preventing translocation of peptides. Azithromycin has been shown to be active against the following microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis & Chlamydia trachomatis. Azithromycin is rapidly absorbed and widely distributed throughout the body, with tissue concentrations greater than those in plasma. Tissue depletion half-life is 2 - 4 days. Biliary excretion of Azithromycin is a major route of elimination. Over the course of a week 6% of the dose appears in urine.

Indications:
► Upper respiratory tract infections, pharyngitis, tonsillitis.
► Lower respiratory tract infections as bronchitis & pneumonia.
► Skin & soft tissue infections.
► Otitis media.
► Sexually transmitted diseases due to Chlamydia trachomatis & Neisseria gonorrhea.
► Urethritis & cervicitis.

Contraindications:
Azithro-Sed is contraindicated in patients with hypersensitivity to the drug.
Warnings :Azithro-Sed should be used with caution in patients with significant liver disease.

Drug Interaction:
Concomitant use of antacids with Azithro-Sed reduced serum concentration of Azithromycin by 30% .
Concomitant use of Azithro-Sed and digoxin may raise digoxin levels. This possibility should be taken into consideration.

Use during pregnancy and lactation
Azithro-Sed should only be used where altematives are not available .

Dosage & route of administration & duration:
Each dose should be taken 1 hour before meals or 2 hours after meals.
In adults :For sexually transmitted diseases: 1-1.2 g (as a single dose(For other Indications: 500-600 mg daily (for 3 days)
In children:

Weight (Kg)	Dosage
Less than 15	10 mg/kg once daily for 3 days
15-25	200 mg (5ml) once daily for 3 days
26-35	300 mg (7.5ml) once daily for 3 days
36-45	400 mg (10ml) once daily for 3 days
More than 45	As for adults

Adverse effects:
Side effects are transient. They include gastrointestinal disturbances, vomiting. constipation and flatulence .Hearing impairment, allergic reactions, asthenia and elevated liver enzymes have been rarely reported.

Storage:
Keep at temp. not exceeding 30ºC
Keep medicine out of reach of children.

Presentation:
Box of 6 capsules 250 mg .
Box of 6 capsules 600 mg.
Bottle of powder for oral suspension ( 15 ml ) .