Angikinase is indicated in cases of:
- Pulmonary embolism
- Coronary artery thrombosis and myocardial infarction
- Deep venous thrombosis (or venous thrombo-embolism)
- Peripheral arterial thrombo-embolism
- Some cases of peritonitis.
Dosage and administration:
cases of Pulmonary Embolism and Deep Venous Thrombosis:
|Priming infusion dose
||4400 IU/ Kg at a rate of 90 ml /hr
|Continuous infusion dose
||4400 IU Kg at a rate of 15 ml / hr over a period of 12 hrs
Coronary artery Thrombosis and Myocardial Infarction:
- Intracoronary Route:
Before the administration of urokinase prior
bolus 2500 – 10,000 Units of heparin should
be administered through intravenous
Reconstitute three vials of Angikinase
250,000 IU by aseptically adding 5 ml of
sterile water for injection.
Then Angikinase is infused at a rate of 4ml
/min into the occluded artery for a period
up to 2 hours.
- Intravenous route:
Angikinase is also administered at doses of
2 -3million units over 45 – 90 minutes.
Peripheral arterial- thromboembolism:
Urokinase is infused in the clot via a
catheter at a rate of 4000 IU / min and the
catheter is advanced every 2 hours till flow
is resumed. then at a rate of 1000 IU / min
till complete clot lysis occurs.
N.B: Preparation of reconstituted
1. it is important to reconstitute only with
sterile water for injection for injection
2. Do not use bacteriostatic water for
3. To minimize the formation of filaments
avoid shaking the vial during
reconstitution. Only Roll and tilt the vial
4. Do not add other medications to the
5. Because urokinase contains no
preservatives do not reconstitute until
immediately before use.
6. Discard any unused portion of the
Keep your tablets in the pack in which they were
Keep your tablets below 30°C.
Keep your tablets in a safe place where children cannot see or reach them.
Box containing one vial of urokinase 100,000, 250,000 and 500,000 IU
Angikinase in pulmonary enbolism
Urokinase and the mode of action
F.A.Q. about Angikinase