for the 600 mg:
Citric acid anhydrous, mannitol, sodium
bicarbonate, sodium carbonate
anhydrous, trimagnesium dicitrate
sodium, aspartame, povidone k25, allura red &
has a mucolytic activity which acts directly
by splitting the disulfide bonds of
mucoproteins and thus reduces the sputum viscosity and
facilitates its expectoration by the
improves the pulmonary defense mechanism,
phagocytic capacity of
macrophages and so protects lungs from inflammation via its direct-antioxidant
property and indirectly as a precursor of
- Following the oral administration, acetylcistein
is readily absorbed from the
gastrointestinal tract with peak plasma
attained within 2-3 hours. Concentrations
in the lungs are
similar to those in plasma.
About 20% of a dose is excreted in the urine
effervescent instant" is a new pharmaceutical
form that ensures rapid
dissolution, maximal absorption, high bioavailability in a perfectly calibrated
- Mucolytic therapy in cases associated with hyper-viscous mucous secretions.
- Upper respiratory tract disorders such as Chronic sinusitis and secretary otitis media (glue ear)
- Broncho-pulmonary Diseases e.g. Bronchitis, Pneumonia,
Asthmatic Bronchitis, Bronchiectasis, cystic fibrosis
(mucoviscidosis), Pneumoconiosis and
- The routine cleansing of tracheostomy during anesthesia.
- Manifestations associated with smoking & exposure to other irritant inhalers.
Hypersensitivity to the active ingredient or
to any of the constituents.
Acetylcistein is contraindicated for
children under 2 years old.
It is well tolerated.
rarely in overdoses
Nausea, vomiting, heart burn , diarrhea,
bronchospams, angioedema, skin eruption,
tachycardia, tinnitus and precipitation of
cystine, oxalate or urate renal stones
especially with acidic urine.
After proper administration of
acetylcysteine, an increased volume of
liquefied of bronchial secretions may occur.
When cough is inadequate, the open airway
must be maintained by mechanical secretion
When there is a mechanical block due to
foreign body or local accumulation, the
airway should be cleaned by end tracheal
aspiration with or without bronchoscopy.
Asthmatic treated with Acetycysteine should
be watched carefully.
Most patients with bronchospasm are quickly
relieved by the use of bronchodilator given
If bronchospasm progresses, the medication
should be discontinued immediately.
Avoid concomitant administration (two hours
interval) of the drug with the following:
- tetracycline hydrochloride, antitussives &
Acetylcysteine must be used with cautions in patients with
history of peptic ulceration and avoided in
patients with active ulcer, asthma or
Maintain fluids intake (6-8 glasses of water
daily) to avoid formation formation of
cystine renal stones.
Avoid diuretics or forces diuresis.
- Caution should be taken in patients who
complain from hypertension, heart failure,
renal disease, oedema and all cases that
need salt restriction.
Use during pregnancy
Acetylcistein should only used if clearly
needed due to lack of well - controlled
No particular symptoms of over dosages has
been observed, treatment should be
symptomatic and supportive.
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.
10 tetra-laminated aluminum foil sachets
packed in a carton box with a pamphlet.
Acetylcistein SEDICO and The Infertility Disorders