Each suppository contains:
Paracetamol ................................. 0.125 gm
Paracetamol is the
principal active metabolite of phenacetin &
acetanilide, but is associated with less
toxicity. Paracetamol reduces fever by
direct action on the hypothalamus
heat-regulating centers. Paracetamol is
almost as potent as aspirin in inhibiting
prostaglandin synthetase in the CNS, but its
peripheral inhibition of prostaglandin
synthesis is minimal, Paracetamol exerts a
strong analgesic effect by raising the
threshold of response to pain stimuli
.Generally the antipyretic & analgesic
effects of Paracetamol & aspirin are
comparable, but Paracetamol does not inhibit
platelet aggregation, affect prothrombin
response or produce GI ulceration.
- Fever of various etiologies.
- Pain of various origins.
- Common cold, influenza & other febrile conditions.
As analgesic & antipyretic in the presence
of aspirin allergy, haemostatic disturbances
(including anticoagulant therapy) bleeding
diatheses, upper GI disease.
- Used as directed Paracetamol rarely causes side effects however skin eruptions or hematological reactions may occur.
- Over dosage might produce symptoms such as vomiting, gastrointestinal disturbances, renal or liver affection.
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.
Box of 5 suppositories.