Acetaminophen
(Suppositories Pediatric)

Composition:
Each suppository contains:
Paracetamol ................................. 0.125 gm

Properties:
Paracetamol is the principal active metabolite of phenacetin & acetanilide, but is associated with less toxicity. Paracetamol reduces fever by direct action on the hypothalamus heat-regulating centers. Paracetamol is almost as potent as aspirin in inhibiting prostaglandin synthetase in the CNS, but its peripheral inhibition of prostaglandin synthesis is minimal, Paracetamol exerts a strong analgesic effect by raising the threshold of response to pain stimuli .Generally the antipyretic & analgesic effects of Paracetamol & aspirin are comparable, but Paracetamol does not inhibit platelet aggregation, affect prothrombin response or produce GI ulceration.

Indications:
  • Fever of various etiologies.
  • Pain of various origins.
  • Common cold, influenza & other febrile conditions.

As analgesic & antipyretic in the presence of aspirin allergy, haemostatic disturbances (including anticoagulant therapy) bleeding diatheses, upper GI disease.

Adverse effects:
  • Used as directed Paracetamol rarely causes side effects however skin eruptions or hematological reactions may occur.
  • Over dosage might produce symptoms such as vomiting, gastrointestinal disturbances, renal or liver affection.

Storage:
Keep at temp. not exceeding 30°C.
Keep medicine out of reach of children.

Presentation:
Box of 5 suppositories.