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Acetaminophen
(Suppositories Pediatric) |
Composition: |
Each
suppository contains:
Paracetamol.................................0.125
gm
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| Properties: |
Paracetamol is the
principal active metabolite of phenacetin &
acetanilide, but is associated with less
toxicity. Paracetamol reduces fever by
direct action on the hypothalamus
heat-regulating centers. Paracetamol is
almost as potent as aspirin in inhibiting
prostaglandin synthetase in the CNS, but its
peripheral inhibition of prostaglandin
synthesis is minimal, Paracetamol exerts a
strong analgesic effect by raising the
threshold of response to pain stimuli
.Generally the antipyretic & analgesic
effects of Paracetamol & aspirin are
comparable, but Paracetamol does not inhibit
platelet aggregation, affect prothrombin
response or produce GI ulceration.
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| Indications: |
►Fever
of various etiologies.
►Pain of
various origins.
►Common cold,
influenza & other febrile conditions.
As analgesic & antipyretic in the presence
of aspirin allergy, haemostatic disturbances
(including anticoagulant therapy(bleeding
diatheses, upper GI disease. |
| Adverse
effects: |
►Used
as directed Paracetamol rarely causes side
effects however skin eruptions or
hematological reactions may occur.
►Over dosage
might produce symptoms such as vomiting,
gastrointestinal disturbances, renal or
liver affection.
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| Storage: |
Keep at temp.
not exceeding 30°C.
Keep medicine out of reach of children.
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| Presentation: |
Box of 5 suppositories.
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